ggh - ggh

1.Gamma-glutamyl hydrolase is an enzyme that hydrolyzes gamma-glutamyl bonds in folates and other compounds. It is encoded by the GGH gene and has various functions and expressions luffy egghead in different tissues and species

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2.GGH is an enzyme that hydrolyzes polyglutamylated folate, which affects SAM-dependent methylation reactions. This study shows that GGH overexpression or inhibition alters global and gene-specific DNA methylation and gene expression in HCT116 ggh 242 MDA-MB-435 cells.Gamma-glutamyl hydrolase EC 3.4.19.9 catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. Cloning and Expression. Yao et al. 1996 cloned and characterized a cDNA for human GGH. The cDNA encodes a 318-amino acid protein with a deduced ...Gamma-glutamyl hydrolase GGH is a lysosomal enzyme involved in the metabolism of folates and anti-folates. It acts as an endo- and/or exo-peptidase to cleave gamma-polyglutamate chains that are attached to folates and anti-folates after they enter a mammalian cell

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